Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus under different fed-batch conditions
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منابع مشابه
PRODUCTION OF CLAVULANIC ACID AND CEPHAMYCIN C BY Streptomyces clavuligerus UNDER DIFFERENT FED-BATCH CONDITIONS
The effect of carbon source and feeding conditions on the production of clavulanic acid (CA) and cephamycin C (CephC) by Streptomyces clavuligerus was investigated. In fed-batch experiments performed with glycerol feeding, production of CA exceeded that of CephC, and reached 1022 mg.L. Highest CephC production (566.5 mg.L) was obtained in fed-batch cultivation with glycerol feeding. In fed-batc...
متن کاملA STUDY ON CLAVULANIC ACID PRODUCTION BY Streptomyces clavuligerus IN BATCH, FED-BATCH AND CONTINUOUS PROCESSES
Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasi...
متن کاملCoordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus.
Production of cephamycin c and clavulanic acid by Streptomyces clavuligerus was investigated using different media in shake flask condition. Highest cell growth (3.8 g/L) was observed in glycerol, sucrose, proline and glutamic acid (GSPG) medium. Although, GSPG medium supported maximum growth, it was least effective for the synthesis of both cephamycin and clavulanic acid. Yield of cephamycin a...
متن کاملDissociation of cephamycin C and clavulanic acid biosynthesis by 1,3-diaminopropane in Streptomyces clavuligerus.
Streptomyces clavuligerus produces simultaneously cephamycin C (CephC) and clavulanic acid (CA). Adding 1,3-diaminopropane to culture medium stimulates production of beta-lactam antibiotics. However, there are no studies on the influence of this diamine on coordinated production of CephC and CA. This study indicates that 1,3-diaminopropane can dissociate CephC and CA productions. Results indica...
متن کاملProduction of Clavulanic Acid by Streptomyces clavuligerus in Batch Cultures with Using Wheat Bran as the Source of Carbon
Nowadays Microbial biotechnology is considered as one of the most important and profitable branches of industry. In this approach, by using the generator microorganisms, We are able to produce biotechnological products, with higher efficiency. Clavulanic acid is being used in combination with commonly used beta-lactam antibiotics in order to fight against bacterial infections that are resistant...
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ژورنال
عنوان ژورنال: Brazilian Journal of Chemical Engineering
سال: 2013
ISSN: 0104-6632
DOI: 10.1590/s0104-66322013000200004